Viral taxonomy derived from evolutionary genome relationships.

Viral taxonomy derived from evolutionary genome relationships.

We describe a brand new genome alignment-based mannequin for understanding the range of viruses based mostly on evolutionary genetic relationships. This strategy makes use of data principle and a bodily mannequin to find out the knowledge shared by the genes in two genomes.

Pairwise comparisons of genes from the viruses are created from alignments utilizing NCBI BLAST, and their match scores are mixed to supply a metric between genomes, which is in flip used to find out a worldwide classification utilizing the 5,817 viruses on RefSeq. In circumstances the place there isn’t a measurable alignment between any genes, the tactic falls again to a coarser measure of genome relationship: the mutual data of 4-mer frequency.

This ends in a principled mannequin which relies upon solely on the genome sequence, which captures many attention-grabbing relationships between viral households, and which creates clusters which correlate effectively with each the Baltimore and ICTV classifications. The incremental computational price of classifying a novel virus is low and due to this fact newly found viruses might be rapidly recognized and categorised.

The mannequin goes past alignment-free classifications by producing a full phylogeny much like these constructed by virologists utilizing qualitative options, whereas relying solely on goal genes.

These outcomes bolster the case for mathematical fashions in microbiology which may characterize organisms utilizing solely their genetic materials and supply an unbiased verify for phylogenies constructed by people, significantly quicker and extra cheaply than much less trendy approaches.

Viral taxonomy derived from evolutionary genome relationships.
Viral taxonomy derived from evolutionary genome relationships.

Malaria Molecular Epidemiology: An Evolutionary Genetics Perspective.

Malaria is a vector-borne illness that entails a number of parasite species in quite a lot of ecological settings. However, the parasite species inflicting the illness, the prevalence of subclinical infections, the emergence of drug resistance, the scale-up of interventions, and the ecological components affecting malaria transmission, amongst others, are points that change throughout areas the place malaria is endemic.

NPL

enz-125 5µg
EUR 60
Description: Recombinant Human N-acetylneuraminate Pyruvate Lyase

NPL siRNA

20-abx926257
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  • 15 nmol
  • 30 nmol

NPL siRNA

20-abx926258
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  • 15 nmol
  • 30 nmol

NPL siRNA

20-abx903621
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  • 15 nmol
  • 30 nmol

NPL Antibody

42953 100ul
EUR 319

NPL Antibody

42953-100ul 100ul
EUR 302.4

NPL Antibody

1-CSB-PA874830LA01HU
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  • 100ug
  • 50ug
Description: A polyclonal antibody against NPL. Recognizes NPL from Human, Mouse. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IF; Recommended dilution: WB:1:2000-1:10000, IF:1:50-1:200

NPL Antibody

E042953 100μg/100μl
EUR 255
Description: Available in various conjugation types.

NPL Antibody

1-CSB-PA015994GA01HU
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  • 150ul
  • 50ul
Description: A polyclonal antibody against NPL. Recognizes NPL from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IF

NPL Antibody

E99210 100ul
EUR 255
Description: Available in various conjugation types.

NPL Antibody

E307920 200ul
EUR 275
Description: Available in various conjugation types.

NPL Antibody

CAC08185-100ug 100ug
EUR 314

NPL Antibody

CAC08185-50ug 50ug
EUR 199.2

NPL antibody

70R-18938 50 ul
EUR 289
Description: Rabbit polyclonal NPL antibody

NPL Antibody

GWB-MW813C 50ug Ask for price

NPL Rabbit pAb

A9210-100ul 100 ul
EUR 369.6

NPL Rabbit pAb

A9210-200ul 200 ul
EUR 550.8

NPL Rabbit pAb

A9210-20ul 20 ul
EUR 219.6

NPL Rabbit pAb

A9210-50ul 50 ul
EUR 267.6

NPL Rabbit pAb

E2511304 100ul
EUR 225
Description: Available in various conjugation types.

NPL Rabbit pAb

E2823828 100ul
EUR 225
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

anti- NPL antibody

FNab05820 100µg
EUR 606.3
Description: Antibody raised against NPL

Human NPL Antibody

32962-05111 150 ug
EUR 215

NPL cloning plasmid

CSB-CL874830HU1-10ug 10ug
EUR 279.6
Description: A cloning plasmid for the NPL gene.

NPL cloning plasmid

CSB-CL874830HU2-10ug 10ug
EUR 279.6
Description: A cloning plasmid for the NPL gene.

NPL cloning plasmid

CSB-CL874830HU3-10ug 10ug
EUR 279.6
Description: A cloning plasmid for the NPL gene.

Npl (GFP-tagged) - Mouse N-acetylneuraminate pyruvate lyase (Npl)

MG204619 10 µg Ask for price

Npl (untagged) - Mouse N-acetylneuraminate pyruvate lyase (Npl), (10ug)

MC201623 10 µg Ask for price

NPL Conjugated Antibody

C42953 100ul
EUR 476.4

NPL Polyclonal Antibody

E-AB-65615-120uL 120uL
EUR 320
Description: Unconjugated

NPL Polyclonal Antibody

E-AB-65615-200uL 200uL
EUR 530
Description: Unconjugated

NPL Polyclonal Antibody

E-AB-65615-60uL 60uL
EUR 200
Description: Unconjugated

NPL Polyclonal Antibody

E-AB-65615-each each Ask for price
Description: Unconjugated

Npl (Myc-DDK-tagged) - Mouse N-acetylneuraminate pyruvate lyase (Npl)

MR204619 10 µg Ask for price

NPL ELISA KIT|Human

EF001304 96 Tests
EUR 826.8

NPL protein (His tag)

80R-1785 100 ug
EUR 307
Description: Purified recombinant Human NPL protein

Rat NPL shRNA Plasmid

20-abx989297
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  • 150 µg
  • 300 µg

Npl (untagged ORF) - Rat N-acetylneuraminate pyruvate lyase (Npl), (10 ug)

RN203441 10 µg Ask for price

Mouse NPL shRNA Plasmid

20-abx978080
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  • 150 µg
  • 300 µg

Human NPL shRNA Plasmid

20-abx962939
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  • 150 µg
  • 300 µg

NPL Antibody, HRP conjugated

1-CSB-PA874830LB01HU
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  • 100ug
  • 50ug
Description: A polyclonal antibody against NPL. Recognizes NPL from Human. This antibody is HRP conjugated. Tested in the following application: ELISA

OOPA00135-5UG - NPL Protein

OOPA00135-5UG 5ug
EUR 70

NPL Recombinant Protein (Rat)

RP214349 100 ug Ask for price

NPL Antibody, FITC conjugated

1-CSB-PA874830LC01HU
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  • 100ug
  • 50ug
Description: A polyclonal antibody against NPL. Recognizes NPL from Human. This antibody is FITC conjugated. Tested in the following application: ELISA

OACA10741-50UG - NPL Antibody

OACA10741-50UG 50ug
EUR 179

NPL Recombinant Protein (Human)

RP021538 100 ug Ask for price

NPL Recombinant Protein (Human)

RP041722 100 ug Ask for price

NPL Recombinant Protein (Human)

RP041725 100 ug Ask for price

NPL Recombinant Protein (Mouse)

RP154721 100 ug Ask for price

NPL Antibody, Biotin conjugated

1-CSB-PA874830LD01HU
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  • 100ug
  • 50ug
Description: A polyclonal antibody against NPL. Recognizes NPL from Human. This antibody is Biotin conjugated. Tested in the following application: ELISA

OACA10741-100UG - NPL Antibody

OACA10741-100UG 100ug
EUR 319

NPL Rabbit Polyclonal Antibody

E10G09133 100 μl
EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

NPL Rabbit Polyclonal Antibody

E10G02156 100 μl
EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

Npl ORF Vector (Rat) (pORF)

ORF071451 1.0 ug DNA
EUR 607.2

NPL ORF Vector (Human) (pORF)

ORF013908 1.0 ug DNA
EUR 424.8

NPL ORF Vector (Human) (pORF)

ORF013909 1.0 ug DNA
EUR 424.8

NPL ORF Vector (Human) (pORF)

ORF007180 1.0 ug DNA
EUR 114

Npl ORF Vector (Mouse) (pORF)

ORF051575 1.0 ug DNA
EUR 607.2

Npl (Myc-DDK-tagged ORF) - Rat N-acetylneuraminate pyruvate lyase (Npl), (10 ug)

RR203441 10 µg Ask for price

Human NPL knockout cell line

ABC-KH10266 1 vial Ask for price
Description: Human NPL knockout cell line is HEK293/HeLa cell line, edited by CRISPR/Cas9 technology.

Lenti ORF clone of Npl (mGFP-tagged) - Mouse N-acetylneuraminate pyruvate lyase (Npl)

MR204619L4 10 µg Ask for price

Human NPL knockdown cell line

ABC-KD10266 1 vial Ask for price
Description: Human NPL knockdown cell line is engineered by our optimized transduction of the specific shRNA with lentivirus. Knockdown levels are determined via qRT-PCR. Gentaur offers generation of stable knockdown (RNAi) cell lines expressing shRNAs targeting genes of your interest.

Human NPL Protein Lysate 20ug

IHUNPLPLLY20UG each
EUR 213
Description: Human NPL Protein Lysate 20ug

GlycoBind Binding Buffer - NPL/NPA

21510901-1 10 mL
EUR 18.65

GlycoBind Binding Buffer - NPL/NPA

21510901-2 25 mL
EUR 41.18

GlycoBind Binding Buffer - NPL/NPA

21510901-3 100 mL
EUR 63.08

GlycoElute Elution Buffer - NPL/NPA

21511300-1 10 mL
EUR 27.38

GlycoElute Elution Buffer - NPL/NPA

21511300-2 25 mL
EUR 45.77

GlycoElute Elution Buffer - NPL/NPA

21511300-3 50 mL
EUR 73.75

Human NPL Antibody (Biotin Conjugate)

32962-05121 150 ug
EUR 315

OCOA07917-20UG - NPL Protein Lysate

OCOA07917-20UG 20ug
EUR 169

NPL Over-expression Lysate Product

GWB-B3DC9B 0.1 mg Ask for price

Lenti ORF clone of Npl (Myc-DDK-tagged) - Mouse N-acetylneuraminate pyruvate lyase (Npl)

MR204619L3 10 µg Ask for price

N-Acetylneuraminate Lyase (NPL) Antibody

abx122123-100ug 100 ug
EUR 469.2

N-Acetylneuraminate Lyase (NPL) Antibody

20-abx124803
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  • 100 ul
  • 200 ul
  • 20 ul
  • 50 ul

N-Acetylneuraminate Lyase (NPL) Antibody

20-abx113976
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  • 150 ul
  • 50 ul

N-Acetylneuraminate Lyase (NPL) Antibody

abx030633-400ul 400 ul
EUR 627.6

N-Acetylneuraminate Lyase (NPL) Antibody

abx030633-80l 80 µl
EUR 343.2

Narcissus pseudonarcissus lectin (NPA/NPL

05-0119-10 10 mg
EUR 277.2

Narcissus pseudonarcissus lectin (NPA/NPL

05-0119-1000 1 g Ask for price

Narcissus pseudonarcissus lectin (NPA/NPL

05-0119-50 50 mg
EUR 866.4

N-Acetylneuraminate Lyase (NPL) Antibody

abx235820-100ug 100 ug
EUR 577.2

N-Acetylneuraminate Lyase (NPL) Antibody

20-abx317934
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  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

N-Acetylneuraminate Lyase (NPL) Antibody

abx113976-100l 100 µl
EUR 612.5

N-Acetylneuraminate Lyase (NPL) Antibody

abx122123-100l 100 µl Ask for price

N-Acetylneuraminate Lyase (NPL) Antibody

abx122123-20l 20 µl
EUR 337.5

N-Acetylneuraminate Lyase (NPL) Antibody

abx122123-50l 50 µl Ask for price

N-Acetylneuraminate Lyase (NPL) Antibody

abx030633-400l 400 µl
EUR 518.75

N-Acetylneuraminate Lyase (NPL) Antibody

abx235820-100g 100 µg
EUR 350

N-Acetylneuraminate Lyase (NPL) Antibody

abx124803-100l 100 µl
EUR 175

N-Acetylneuraminate Lyase (NPL) Antibody

abx124803-1ml 1 ml
EUR 400

N-Acetylneuraminate Lyase (NPL) Antibody

abx124803-200l 200 µl
EUR 275

N-Acetylneuraminate Lyase (NPL) Antibody

abx317934-100g 100 µg
EUR 362.5

N-Acetylneuraminate Lyase (NPL) Antibody

abx317934-20g 20 µg
EUR 162.5

N-Acetylneuraminate Lyase (NPL) Antibody

abx317934-50g 50 µg
EUR 250

NPL (untagged)-Human N-acetylneuraminate pyruvate lyase (dihydrodipicolinate synthase) (NPL), transcript variant 1

SC109402 10 µg Ask for price

NPL (untagged) - Human N-acetylneuraminate pyruvate lyase (dihydrodipicolinate synthase) (NPL), transcript variant 5

SC334644 10 µg Ask for price

Lenti ORF particles, Npl (GFP-tagged) - Mouse N-acetylneuraminate pyruvate lyase (Npl), 200ul, >10^7 TU/mL

MR204619L4V 200 µl Ask for price

Npl sgRNA CRISPR Lentivector set (Rat)

K6323701 3 x 1.0 ug
EUR 406.8

NPL (GFP-tagged) - Human N-acetylneuraminate pyruvate lyase (dihydrodipicolinate synthase) (NPL), transcript variant 1

RG214546 10 µg Ask for price

NPL sgRNA CRISPR Lentivector set (Human)

K1446501 3 x 1.0 ug
EUR 406.8

Npl sgRNA CRISPR Lentivector set (Mouse)

K4700701 3 x 1.0 ug
EUR 406.8

NPL (untagged) - Homo sapiens N-acetylneuraminate pyruvate lyase (dihydrodipicolinate synthase) (NPL), transcript variant 2

SC329614 10 µg Ask for price

NPL (untagged) - Homo sapiens N-acetylneuraminate pyruvate lyase (dihydrodipicolinate synthase) (NPL), transcript variant 4

SC331402 10 µg Ask for price

NPL (untagged) - Homo sapiens N-acetylneuraminate pyruvate lyase (dihydrodipicolinate synthase) (NPL), transcript variant 3

SC331405 10 µg Ask for price

Lenti ORF clone of Npl (mGFP-tagged ORF) - Rat N-acetylneuraminate pyruvate lyase (Npl), (10 ug)

RR203441L4 10 µg Ask for price

Lenti ORF particles, Npl (GFP-tagged ORF) - Rat N-acetylneuraminate pyruvate lyase (Npl), 200ul, >10^7 TU/mL

RR203441L4V 200 µl Ask for price

Narcissus pseudonarcissus Lectin (NPL/NPA) - Cy3

21761126-1 1 mg
EUR 134.51

Narcissus pseudonarcissus Lectin (NPL/NPA) - Cy5

21761127-1 1 mg
EUR 134.51

N-Acetylneuraminate Lyase (NPL) Antibody (HRP)

20-abx316724
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  • Ask for price
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

N-Acetylneuraminate Lyase (NPL) Antibody (HRP)

abx316724-100g 100 µg
EUR 362.5

N-Acetylneuraminate Lyase (NPL) Antibody (HRP)

abx316724-20g 20 µg
EUR 162.5

N-Acetylneuraminate Lyase (NPL) Antibody (HRP)

abx316724-50g 50 µg
EUR 250

Lenti ORF particles, Npl (Myc-DDK-tagged) - Mouse N-acetylneuraminate pyruvate lyase (Npl), 200ul, >10^7 TU/mL

MR204619L3V 200 µl Ask for price

Narcissus pseudonarcissus Lectin (NPL/NPA) - Pure

21510256-1 2 mg
EUR 120.4

Narcissus pseudonarcissus Lectin (NPL/NPA) - Pure

21510256-2 5 mg
EUR 132.24

N-Acetylneuraminate Lyase (NPL) Antibody (FITC)

20-abx316725
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  • Ask for price
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Human N-Acetylneuraminate Lyase (NPL) Protein

abx073214-20kDa1g 20 kDa; 1 g
EUR 225

Human N-Acetylneuraminate Lyase (NPL) Protein

abx073214-20kDa5g 20 kDa; 5 g
EUR 325

Human N-Acetylneuraminate Lyase (NPL) Protein

abx073214-20kDa60g 20 kDa; 60 g
EUR 3550

Such complexities have propelled the examine of parasite genetic range patterns within the context of epidemiologic investigations. Importantly, molecular research point out that the time and spatial distribution of malaria circumstances replicate epidemiologic processes that can not be absolutely understood with out characterizing the evolutionary forces shaping parasite inhabitants genetic patterns. Although broad in scope, this evaluation within the Microbiology Spectrum Curated Collection: Advances in Molecular Epidemiology highlights the necessity for understanding inhabitants genetic ideas when decoding parasite molecular knowledge.

First, we focus on malaria complexity when it comes to the parasite species concerned. Second, we describe how molecular knowledge are altering our understanding of malaria incidence and infectiousness. Third, we examine completely different approaches to generate parasite genetic data within the context of epidemiologically related questions associated to malaria management. Finally, we describe a couple of Plasmodium genomic research as proof of how these approaches will present new insights into the malaria illness dynamics. *This article is a part of a curated assortment.

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